The thermodynamics of protein interactions with essential first row transition metals
نویسندگان
چکیده
منابع مشابه
Density Functional Calculations on First-Row Transition Metals
The excitation energies and ionization potentials of the atoms in the first transition series are notoriously difficult to compute accurately. Errors in calculated excitation energies can range from 1–4 eV at the Hartree-Fock level, and errors as high as 1.5eV are encountered for ionization energies. In the current work we present and discuss the results of a systematic study of the first trans...
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Reactions between [M'(III)(CN)(6)](3-) anions (M' = Co, Cr, or Fe) and mononuclear complexes of M(II) ions (M = Cr, Mn, Co, Ni, or Zn) produce a family of pentanuclear clusters {[M(tmphen)(2)](3)[M'(CN)(6)](2)]}. The core of the clusters is formed by five metal ions that are bridged through six CN- linkers into a trigonal bipyramid, with M and M' ions occupying equatorial and axial positions of...
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Platinum compounds are a mainstay of cancer chemotherapy, with over 50% of patients receiving platinum. But there is a great need for improvement. Major features of the cisplatin mechanism of action involve cancer cell entry, formation mainly of intrastrand cross-links that bend and unwind nuclear DNA, transcription inhibition and induction of cell-death programmes while evading repair. Recentl...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2016
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2015.11.005